After 30 days, those who took either dose of ashwagandha self-reported positive effects on their anxiety. Some symptoms of high thyroid hormone levels include fatigue, increased appetite, sweating, restlessness, diarrhea, hair loss, insomnia, itching and high blood pressure. With such a long list of claims, it's important to look closely at the research. National Institutes of Health Office of Dietary Supplements. PLoS.One. These medications work in the brain by indirectly enhancing the action of a chemical in the brain called gamma-aminobutyric acid (GABA) a neurotransmitter that has a calming effect which helps lower anxiety levels. 2020;34(5):1041-1059. The liver damage never progressed to liver failure, and most cases were resolved within five months. Therefore, before using this product, tell your doctor or pharmacist of all the . DISCLAIMER: Currently this does not check for drug . Prez-Gmez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Avoid beer, wine, and mixed drinks (alcohol) while taking this product. Lower ashwagandha doses of 225 milligrams per day to 400 milligrams per day have been associated with perceived improvements in stress and anxiety. Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. J Pharm Pharmacol 1998;50:1065-68. It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. View abstract. Dasgupta A, Tso G, Wells A. Ashwagandha - More Interactions. J Atten Disord 2010;14:281-91. Dhuley, J. N. Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice. Phytotherapy Research 1991;5:111-114. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. 2020;12(4):1119. The most common side effects include: Other less common side effects of ashwagandha include: If you experience side effects when taking ashwagandha, be sure to stop using it and seek advice from a healthcare provider. View abstract. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Evid Based Complement Alternat Med. Do note that ashwagandha itself does not . Can I Take Lexapro & Vitamin Supplements? 4. Therapeutic Research Faculty 2020. There is animal research that suggests that ashwagandha may lower systolic and diastolic blood pressure, putting people who take blood pressure-lowering medication at risk for hypotension,. View abstract. All rights reserved. Afewerky HK, Ayodeji AE, Tiamiyu BB, et al. View abstract. First and foremost, I want to point out this it can tricky to determine whether or not a dietary/herbal supplement will interact with prescription drugs due to a general lack of studies on the matter. J Ethnopharmacol 1999;67:27-35. Withania somnifera (Indian ginseng) in diabetes mellitus: A systematic review and meta-analysis of scientific evidence from experimental research to clinical application. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. It is very widely utilized as a dietary supplement and used for a number of purported medical benefits, including: As ashwagandha is a botanical, it appears to have many different active components and a complex mechanism of action for how it works. doi:10.1002/brb3.1760, Adalier N, Parker H. Vitamin E, turmeric and saffron in treatment of Alzheimer's disease. 2021 Nov 25;13(2):100510. View abstract. 8 Warning Signs of Depression You Shouldn't Ignore, Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, How Vegans Can Get All Their Nutrients (Without Taking Supplements), Complementary Therapies in Medicine Journal, 15 Celebrities Who Struggle With Anxiety and Depression, Australian Journal of Herbal Medicine: "B Vitamins Enhance Antidepressant Response in Adults", Open Neurology Journal: "Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial", Journal of Psychiatry: "Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses", Mayo Clinic: "MAOIs and Diet: Is It Necessary to Restrict Tyramine? For example, ashwagandha (botanical name, Withania somnifera) is an herbal supplement found in anything from green smoothie mixes to root powder. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Withania somnifera, also commonly as ashwagandha or winter cherry, is a shrub native to parts of Asia and Africa. 1988;26(11):877-882. Can You Take Lyrica And Flexeril Together? Xanax is used to treat the following conditions: Anxiety; Panic Disorder; Drug and food interactions Similar results were reported in another study that examined ashwagandha's effect on attaining quality sleep. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. It also covers possible side effects of the herb, interactions, dosage information, and guidance regarding selecting ashwagandha supplements. Ashwagandha may lower blood sugar (i.e. Thyroid Suppression Test. It may also interact with other herbs, supplements, and even foods. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. According to the NIH, ashwagandha may interact with certain prescription medications, including antidiabetes drugs, antihypertensive drugs, immunosuppressants, benzodiazepines, certain sedative . Is It Safe To Take Keflex (Cephalexin) With Birth Control? Since you don't mention any drugs in your question, we'll list some of the potential interactions below. Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. However, there is concern that herbs like ashwagandha may have interactions that have . There is concern that ashwagandha interacts with anesthesia commonly used in surgery. View abstract. Staff, Cotellic With Turmeric And Black Pepper Interaction. Historically, ashwagandha has been thought of as a possible stimulant for athletics since the ancient medical system. Long-term safety studies on ashwagandha are lacking. Ghosal S, Lal J, Srivastava R, and et al. Levothyroxine is in the drug class thyroid drugs . It is recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha out of an abundance of caution. ", Mayo Clinic: "Selective Serotonin Reuptake Inhibitors (SSRIs)", Cleveland Clinic: "Depression Medicines: Risks / Benefits", Shanghai Archives of Psychiatry: "Use of Antipsychotics in the Treatment of Depressive Disorders", Food and Drug Administration: "Vitamins and Minerals Chart", World Journal of Biological Chemistry: "Complexity of Vitamin E Metabolism", NCBI Bookshelf: "Depression in Adults With a Chronic Physical Health Problem: Treatment and Management", Journal of Medicine and Life: "Nutrition and Depression at the Forefront of Progress", Harvard Health Publishing: "Cytochrome P450 Enzymes and Psychiatric Drugs", Complementary Therapies in Medicine Journal: "Evaluation of the Efficacy of Withania Somnifera (Ashwagandha) Root Extract in Patients With Obsessive-Compulsive Disorder: A Randomized Double-Blind Placebo-Controlled Trial", Serotonin and norepinephrine reuptake inhibitors (SNRIs), Norepinephrine and dopamine reuptake inhibitors (NDRIs), Noncompetitive N-methyl-D-aspartate receptor antagonists. There are no vitamins contraindicated for consumption with antidepressants, but you should be cautious about consuming a mixture of supplements. J.Transl.Med. This product can contain high amounts of iron. Study participants were randomized to receive a placebo, 225 milligrams per day of ashwagandha, or 400 milligrams per day of ashwagandha for 30 days. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. People with thyroid conditions or who are taking thyroid medications should talk with a healthcare provider before using ashwagandha. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. View abstract. Additionally, a pilot study looked at ashwagandha's effects on people with mild cognitive impairment. View abstract. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. Underactive Thyroid. It may also interact with other herbs, supplements, and even foods. Ashwagandha may be toxic to the liver (hepatotoxic). 2004;42(12):2015-2020. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. Ashwagandha has mild interactions with at least 29 different drugs. View abstract. Cancer Lett 2000;148:9-17. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. It's much more likely for certain foods, like grapefruit juice or herbal supplements, to affect antidepressant function. WebMD does not provide medical advice, diagnosis or treatment. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. You should also review supplement labels with a healthcare provider to discuss any potential interactions with foods, other supplements, and medications. Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Discard any remaining ashwagandha supplements once they expire or as indicated on the packaging. Dosage: How Much Ashwagandha Should I Take? Ashwagandha and other dietary supplements should never replace standard medicine or care. 2013;45(4):417-8. Yakugaku Zasshi 2008;128(8):1159-1167. Therefore, it should be used cautiously with drugs used to treat diabetes, including: Just like with potential interactions between ashwagandha and diabetes drugs, there may be a potential issue with drugs used to treat high blood pressure as studies show ashwagandha mayhave blood-pressure-lowering effects. 1965;9(1):9-15. J Res Ayur Sid 1980;1:370-385. Does Synthroid interact with supplements that may help with arthritis, such as ashwagandha, collagen, or turmeric? From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. View abstract. View abstract. J Med Food 2022. Use birth control you can trust while taking this product. Taking ashwagandha along with sedative medications might cause too much sleepiness. Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. Ashwagandha interferes with immunoassay measurements of digoxin, a medication primarily used for treating congestive heart failure and abnormal heart rhythms. If you're interested in taking a nutritional supplement to support your treatment for depression, talk to your doctor so you can find the one that works best for you and doesn't affect your antidepressants. Monitor your blood sugar closely. Its scientific name is Withania somnifera Dunal, and it belongs to a class of herbs called rasayana, praised for their revitalizing effects on health. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. Take extra care driving and doing tasks that you need to be alert for while taking this product. Does Ashwagandha Interact With Any Medications? The roots can be used topically as a poult. Liver Int. In rare cases, the use of ashwagandha may lead to liver damage. Of note, the benefits were strongest in those who took at least 600 milligrams per day of ashwagandha for at least eight weeks. PLoS One 2009;4:e6628. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. This includes people who have had a transplant, are on chemo, or have an autoimmune disease. The combination could result in excess thyroid hormone in the body, which has many negative effects. Phytother Res 2022. This means not enough is known about either the safety or effectiveness of taking daily ashwagandha for an extended period of time. Hidese S, Ogawa S, Ota M, et al. Ultimately, the supplements and foods you can safely ingest depend entirely on the antidepressant. One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. 1985;23(4):177-183. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. You can also connect with Dr. Brian Staiger on LinkedIn. Many of the studies on ashwagandha have been performed in laboratory settings or on animal models, but some human trials do exist. Chauhan S, Srivastava MK, Pathak AK. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. Nutrients. 2013;2013:571420. Ashwagandha Root (Withania somnifera): Analytical, quality control, and therapuetic monograph. View abstract. View abstract. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: a randomized controlled trial. Ashwagandha may interact with various medications. Ashwagandha can react with certain medications and supplements you may already take, and result in adverse effects. blood glucose). Moderate 623 Interactions; Unknown 2123 Interactions; Interaction Rating Key. These supplements may contain similar active ingredients or have potential uses that are like those of ashwagandha. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and check in about potential interactions with other supplements or medications. Medicine (Baltimore). However, scientific evidence supporting these and other uses is poor. Headache. Ahumada F, Aspee F, Wikman G, and et al. J Ethnopharmacol 1991;33:91-5. Twelve studies were included in the final review, and researchers concluded that ashwagandha showed more improvements in physical performance than placebo pills.

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